2024 Trend Updates: What Really Works In SEO & Content MarketingSearch Engine Journal
The future of SEO is trending toward a more human-first and user-centric approach, powered by AI intelligence and collaboration. Are you ready?
Watch as we explore which SEO trends to prioritize to achieve sustainable growth and deliver reliable results. We’ll dive into best practices to adapt your strategy around industry-wide disruptions like SGE, how to navigate the top challenges SEO professionals are facing, and proven tactics for prioritizing quality and building trust.
You’ll hear:
- The top SEO trends to prioritize in 2024 to achieve long-term success.
- Predictions for SGE’s impact, and how to adapt.
- What E-E-A-T really means, and how to implement it holistically (hint: it’s never been more important).
With Zack Kadish and Alex Carchietta, we’ll show you which SEO trends to ignore and which to focus on, along with the solution to overcoming rapid, significant and disruptive Google algorithm updates.
If you’re looking to cut through the noise of constant SEO and content trends to drive success, you won’t want to miss this webinar.
Storytelling For The Web: Integrate Storytelling in your Design ProcessChiara Aliotta
In this slides I explain how I have used storytelling techniques to elevate websites and brands and create memorable user experiences. You can discover practical tips as I showcase the elements of good storytelling and its applied to some examples of diverse brands/projects..
This presentation by Thibault Schrepel, Associate Professor of Law at Vrije Universiteit Amsterdam University, was made during the discussion “Artificial Intelligence, Data and Competition” held at the 143rd meeting of the OECD Competition Committee on 12 June 2024. More papers and presentations on the topic can be found at oe.cd/aicomp.
This presentation was uploaded with the author’s consent.
How to Leverage AI to Boost Employee Wellness - Lydia Di Francesco - SocialHR...SocialHRCamp
Speaker: Lydia Di Francesco
In this workshop, participants will delve into the realm of AI and its profound potential to revolutionize employee wellness initiatives. From stress management to fostering work-life harmony, AI offers a myriad of innovative tools and strategies that can significantly enhance the wellbeing of employees in any organization. Attendees will learn how to effectively leverage AI technologies to cultivate a healthier, happier, and more productive workforce. Whether it's utilizing AI-powered chatbots for mental health support, implementing data analytics to identify internal, systemic risk factors, or deploying personalized wellness apps, this workshop will equip participants with actionable insights and best practices to harness the power of AI for boosting employee wellness. Join us and discover how AI can be a strategic partner towards a culture of wellbeing and resilience in the workplace.
2024 State of Marketing Report – by HubspotMarius Sescu
https://www.hubspot.com/state-of-marketing
· Scaling relationships and proving ROI
· Social media is the place for search, sales, and service
· Authentic influencer partnerships fuel brand growth
· The strongest connections happen via call, click, chat, and camera.
· Time saved with AI leads to more creative work
· Seeking: A single source of truth
· TLDR; Get on social, try AI, and align your systems.
· More human marketing, powered by robots
ChatGPT is a revolutionary addition to the world since its introduction in 2022. A big shift in the sector of information gathering and processing happened because of this chatbot. What is the story of ChatGPT? How is the bot responding to prompts and generating contents? Swipe through these slides prepared by Expeed Software, a web development company regarding the development and technical intricacies of ChatGPT!
Product Design Trends in 2024 | Teenage EngineeringsPixeldarts
The realm of product design is a constantly changing environment where technology and style intersect. Every year introduces fresh challenges and exciting trends that mold the future of this captivating art form. In this piece, we delve into the significant trends set to influence the look and functionality of product design in the year 2024.
How Race, Age and Gender Shape Attitudes Towards Mental HealthThinkNow
Mental health has been in the news quite a bit lately. Dozens of U.S. states are currently suing Meta for contributing to the youth mental health crisis by inserting addictive features into their products, while the U.S. Surgeon General is touring the nation to bring awareness to the growing epidemic of loneliness and isolation. The country has endured periods of low national morale, such as in the 1970s when high inflation and the energy crisis worsened public sentiment following the Vietnam War. The current mood, however, feels different. Gallup recently reported that national mental health is at an all-time low, with few bright spots to lift spirits.
To better understand how Americans are feeling and their attitudes towards mental health in general, ThinkNow conducted a nationally representative quantitative survey of 1,500 respondents and found some interesting differences among ethnic, age and gender groups.
Technology
For example, 52% agree that technology and social media have a negative impact on mental health, but when broken out by race, 61% of Whites felt technology had a negative effect, and only 48% of Hispanics thought it did.
While technology has helped us keep in touch with friends and family in faraway places, it appears to have degraded our ability to connect in person. Staying connected online is a double-edged sword since the same news feed that brings us pictures of the grandkids and fluffy kittens also feeds us news about the wars in Israel and Ukraine, the dysfunction in Washington, the latest mass shooting and the climate crisis.
Hispanics may have a built-in defense against the isolation technology breeds, owing to their large, multigenerational households, strong social support systems, and tendency to use social media to stay connected with relatives abroad.
Age and Gender
When asked how individuals rate their mental health, men rate it higher than women by 11 percentage points, and Baby Boomers rank it highest at 83%, saying it’s good or excellent vs. 57% of Gen Z saying the same.
Gen Z spends the most amount of time on social media, so the notion that social media negatively affects mental health appears to be correlated. Unfortunately, Gen Z is also the generation that’s least comfortable discussing mental health concerns with healthcare professionals. Only 40% of them state they’re comfortable discussing their issues with a professional compared to 60% of Millennials and 65% of Boomers.
Race Affects Attitudes
As seen in previous research conducted by ThinkNow, Asian Americans lag other groups when it comes to awareness of mental health issues. Twenty-four percent of Asian Americans believe that having a mental health issue is a sign of weakness compared to the 16% average for all groups. Asians are also considerably less likely to be aware of mental health services in their communities (42% vs. 55%) and most likely to seek out information on social media (51% vs. 35%).
Classification of Selective Alpha Agonists Based on Generation
Selective alpha agonists can be classified into first-generation, second-generation, and third-generation based on their pharmacological properties, receptor specificity, and clinical applications.
1. First-Generation Selective Alpha Agonists
(Non-subtype selective, older agents, higher side effects)
These drugs act on α1 or α2 receptors but with lower specificity and more systemic side effects.
Selective α1 Agonists (Vasoconstrictors, Hypotension Treatment)
Methoxamine – Used to treat hypotension.
Phenylephrine – Used as a nasal decongestant and to increase blood pressure.
Midodrine – Used for orthostatic hypotension.
Metaraminol – Used in hypotensive states and shock.
Selective α2 Agonists (Centrally Acting, Anti-Hypertensive Drugs)
Clonidine – Used for hypertension, ADHD, and withdrawal syndromes.
Methyldopa – Used for hypertension, especially in pregnancy.
Guanfacine – Used in hypertension and ADHD.
2. Second-Generation Selective Alpha Agonists
(More receptor selectivity, improved safety profile, fewer side effects)
Selective α1 Agonists (Longer Duration, Specific Targeting)
Amidephrine – Used in hypotension.
Selective α2 Agonists (Better CNS Penetration, Neurological Uses)
Brimonidine – Used in glaucoma (reduces intraocular pressure).
Apraclonidine – Used in short-term treatment of glaucoma.
Tizanidine – Used as a muscle relaxant in spasticity.
Lofexidine – Used in opioid withdrawal treatment.
3. Third-Generation Selective Alpha Agonists
(Highly selective, fewer side effects, newer therapeutic applications)
Selective α2 Agonists (High Selectivity, Novel Applications)
Dexmedetomidine – Used as a sedative in ICU and anesthesia.
Medetomidine – Used in veterinary anesthesia.
Fadolmidine – Investigated for pain relief with fewer cardiovascular effects.
Detomidine – Used in veterinary medicine for sedation
Classification of Selective Beta Agonists Based on Generation
Selective β-adrenergic agonists can be classified into three generations based on their receptor selectivity, duration of action, and therapeutic advancements.
1. First-Generation Selective Beta Agonists
(Non-specific, Short-acting, Higher Side Effects)
Early β-agonists with partial selectivity, often affecting both β1 and β2 receptors.
Shorter duration of action, leading to frequent dosing requirements.
Key Drugs:
Isoproterenol – A non-selective β1 and β2 agonist, used for bradycardia and heart block.
Dobutamine – A selective β1 agonist, used in acute heart failure and cardiogenic shock.
Ritodrine – A selective β2 agonist, previously used for delaying preterm labor.
2. Second-Generation Selective Beta Agonists
(More Selective, Longer Duration, Improved Safety)
These drugs show improved selectivity for either β1 or β2 receptors, reducing unwanted cardiac effects.
Longer-acting compared to first-generation.
Selective β1 Agonists (Primarily Cardiac Stimulants)
Denopamine – Used in heart failure treatment.
Prenalte
Co-Chairs and Presenters, Professor Carel le Roux, MBChB, FRCP, FRCPath, PhD, and Donna H. Ryan, MD, FTOS, discuss obesity in this CME activity titled “Adopting Modern Management Strategies for Obesity: Treating the Patient, Not the Disease.” For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at https://bit.ly/40HfQWa. CME credit will be available until March 27, 2026.
echinocandins case presentation.dr ANKUSH GOYAL GMC PATIALADr Ankush goyal
Echinocandins: A Comprehensive Overview
Introduction
Echinocandins are a class of antifungal agents that have gained significant prominence in the treatment of invasive fungal infections, particularly those caused by Candida and Aspergillus species. They are considered second-line or first-line treatment options in cases of azole-resistant fungal infections. This document provides an in-depth discussion of echinocandins, including their chemical structure, mechanism of action, pharmacokinetics, spectrum of activity, clinical applications, resistance mechanisms, adverse effects, and future perspectives.
Historical Background
Echinocandins were first discovered in the late 20th century when researchers were exploring natural antifungal compounds derived from fungi and other microorganisms. The first echinocandin, pneumocandin B0, was isolated from Glarea lozoyensis. Further modifications led to the development of caspofungin, micafungin, and anidulafungin, which are the three currently approved echinocandins for clinical use.
Chemical Structure
Echinocandins are cyclic lipopeptides composed of a large cyclic hexapeptide core linked to a long-chain fatty acid side group. This unique structure is crucial for their antifungal activity and their pharmacokinetic properties. The lipid tail enhances the compound's binding affinity to fungal cells, while the cyclic peptide core is responsible for inhibiting fungal cell wall synthesis.
Mechanism of Action
Echinocandins exert their antifungal effects by selectively inhibiting the enzyme (1→3)-β-D-glucan synthase, which is essential for the synthesis of β-glucan, a major component of the fungal cell wall. The inhibition of β-glucan synthesis results in cell wall weakening, osmotic instability, and ultimately fungal cell lysis. This mechanism makes echinocandins highly selective for fungi, as mammalian cells lack β-glucan.
Pharmacokinetics
Echinocandins are administered intravenously due to their poor oral bioavailability. The pharmacokinetic properties of caspofungin, micafungin, and anidulafungin vary slightly, but they share several common features:
Distribution: Echinocandins exhibit extensive tissue penetration, particularly in the liver, spleen, lungs, and kidneys. However, their penetration into the cerebrospinal fluid (CSF) is limited, making them less effective for central nervous system fungal infections.
Metabolism: Caspofungin undergoes hepatic metabolism through hydrolysis and N-acetylation, while micafungin is metabolized by the liver via arylsulfatase and catechol-O-methyltransferase. Anidulafungin undergoes spontaneous degradation in the plasma without significant hepatic metabolism.
Elimination: The elimination of echinocandins varies; caspofungin is excreted through both hepatic and renal routes, micafungin is eliminated hepatically, and anidulafungin is primarily excreted via fecal routes due to spontaneous degradation.
Half-life: Caspofungin has a half-life of approximately 9-
The integumentary system is the largest organ system of the human body, serving as the body's first line of defense against environmental hazards. It includes the skin, hair, nails, glands, and sensory receptors. This system plays a vital role in protection, thermoregulation, sensation, excretion, and vitamin D synthesis. Understanding its structure and function is crucial for comprehending how the body interacts with its surroundings.
Structure of the Integumentary System
The integumentary system comprises two main components:
The Skin (Cutaneous Membrane)
Accessory Structures (Hair, Nails, and Glands)
The Skin
The skin, also called the cutaneous membrane, consists of three primary layers:
1. Epidermis
The epidermis is the outermost layer of the skin, composed of stratified squamous epithelium. It lacks blood vessels and is primarily made of keratinocytes, which produce the protective protein keratin. Other important cells in the epidermis include:
Melanocytes – produce melanin, which protects against UV radiation.
Langerhans cells – involved in immune response.
Merkel cells – associated with sensory neurons for touch perception.
The epidermis has five distinct layers (from deep to superficial):
Stratum basale (germinativum) – contains basal cells responsible for generating new keratinocytes.
Stratum spinosum – provides structural integrity.
Stratum granulosum – where keratinization begins.
Stratum lucidum – found only in thick skin (palms and soles).
Stratum corneum – the outermost layer made of dead keratinized cells.
2. Dermis
The dermis is the thicker, connective tissue layer beneath the epidermis. It consists of collagen and elastic fibers, providing strength and flexibility. The dermis has two layers:
Papillary Layer – composed of loose areolar connective tissue; contains dermal papillae, capillaries, and sensory receptors.
Reticular Layer – made of dense irregular connective tissue; contains sweat glands, hair follicles, and blood vessels.
3. Hypodermis (Subcutaneous Layer)
The hypodermis is a layer of adipose and connective tissue that insulates the body, stores energy, and provides cushioning. It connects the skin to underlying muscles and bones.
Functions of the Integumentary System
The skin performs several essential functions, including:
1. Protection
The skin acts as a physical barrier against microorganisms, dehydration, UV radiation, and harmful chemicals. The acid mantle (low pH) of the skin inhibits bacterial growth.
2. Thermoregulation
The skin helps maintain body temperature through:
Sweating (eccrine and apocrine glands) – evaporative cooling.
Vasodilation – blood vessels widen to release heat.
Vasoconstriction – blood vessels narrow to retain heat.
Goosebumps (arrector pili muscles) – create an insulating layer.
3. Sensation
The skin contains specialized sensory receptors:
Meissner’s corpuscles – detect light touch.
Pacinian corpuscles – sense deep pressure and vibration.
Merkel cells –
ASTHMA.pdf FOR NURSING STUDENTS CREATED BY KIRAN KARETHAKIRAN KARETHA
Asthma is defined as a chronic inflammatory disorder of the
airways (specifically bronchi and bronchioles) which
manifests itself as recurrent episodes of wheezing,
breathlessness, chest tightness and cough.
It is characterized by bronchial hyper-responsiveness and
variable airflow obstruction, that is often reversible either
spontaneously or with treatment.
ASTHMA ATTACK:
When breathe normally, muscles around the airways are relaxed,
letting air move easily and quietly. During an asthma attack, three
things can happen:
Bronchospasm: The muscles around the airways constrict (tighten).
When they tighten, it makes the airways narrow. Air cannot flow
freely through constricted airways.
Inflammation: The lining of the airways becomes swollen. Swollen
airways don’t let as much air in or out of the lungs.
Mucus production: During the attack, body creates more mucus.
This thick mucus clogs airways.
CLINICAL MANIFESTATION:
Coughing
Chest tightness
Wheezing
Shortness of breath
Chronic production of cough
Dyspnea
Cyanosis
Weight loss and anorexia
Fatigue
Anxiety
Restlessness
DIAGNOSTIC EVALUATION:
History collection
Physical examination
Chest X-ray
Spirometry
Blood test
Skin test: to identify allergic causes.
Sputum test
PFT
DIAGNOSTIC EVALUATION:
History collection
Physical examination
Chest X-ray
Spirometry
Blood test
Skin test: to identify allergic causes.
Sputum test
PFT
Shoola in Ayurveda Dr Akshay Shetty.pptxAkshay Shetty
This document deals with shoola its definition, types and difference between Parinama shoola ad Annadrava shoola with etiology,Clinical features and prognosis
Learning Objectives:
1. Explain the basis of Nernst potential and its importance in generation of resting membrane potential
2. Comprehend different mechanisms responsible for the genesis of membrane potential
3. Use the Goldman equation to explain how the relative permeability of the ions create a resting membrane potential
Psychopharmacology questions .pdf by Dr ankush goyalDr Ankush goyal
Psychopharmacology: A Comprehensive Overview
Introduction
Psychopharmacology is the scientific study of the effects of drugs on mood, perception, cognition, and behavior. It involves the interaction of drugs with the nervous system, particularly the brain, to alter mental functions and treat psychiatric disorders. Psychopharmacology integrates principles from neuroscience, pharmacology, psychiatry, and psychology to develop effective treatments for mental illnesses such as depression, schizophrenia, anxiety, and bipolar disorder.
History and Development
The field of psychopharmacology has its roots in ancient medicine, where herbal remedies were used to treat mental disorders. Modern psychopharmacology began in the 20th century with the discovery of drugs such as chlorpromazine (antipsychotic) and imipramine (antidepressant), revolutionizing psychiatric care. Over time, research has led to the development of more targeted and effective drugs with fewer side effects.
Neurotransmitter Systems and Drug Actions
Psychotropic drugs exert their effects by modulating neurotransmitter systems in the brain. The major neurotransmitters involved include:
Dopamine (DA): Associated with reward, motivation, and movement; implicated in schizophrenia and Parkinson’s disease.
Serotonin (5-HT): Regulates mood, appetite, and sleep; targeted by antidepressants.
Norepinephrine (NE): Involved in arousal and stress response; plays a role in depression and anxiety.
Gamma-Aminobutyric Acid (GABA): The primary inhibitory neurotransmitter; targeted by anxiolytics and sedatives.
Glutamate: The primary excitatory neurotransmitter; implicated in schizophrenia and cognitive function.
Acetylcholine (ACh): Important for memory and learning; affected in Alzheimer’s disease.
Classification of Psychotropic Drugs
Psychotropic drugs can be classified based on their therapeutic use:
1. Antidepressants
Used to treat depressive disorders, anxiety disorders, and other conditions.
Selective Serotonin Reuptake Inhibitors (SSRIs): Fluoxetine, Sertraline, Citalopram
Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs): Venlafaxine, Duloxetine
Tricyclic Antidepressants (TCAs): Amitriptyline, Imipramine
Monoamine Oxidase Inhibitors (MAOIs): Phenelzine, Selegiline
Atypical Antidepressants: Bupropion, Mirtazapine
2. Antipsychotics
Used to manage schizophrenia, bipolar disorder, and psychotic disorders.
Typical (First-Generation) Antipsychotics: Haloperidol, Chlorpromazine
Atypical (Second-Generation) Antipsychotics: Risperidone, Olanzapine, Clozapine
3. Mood Stabilizers
Used to treat bipolar disorder and mood dysregulation.
Lithium: Effective for bipolar disorder
Anticonvulsants: Valproate, Lamotrigine, Carbamazepine
4. Anxiolytics and Sedative-Hypnotics
Used for anxiety and sleep disorders.
Benzodiazepines: Diazepam, Lorazepam, Alprazolam
Non-Benzodiazepine Hypnotics: Zolpidem, Eszopiclone
Barbiturates: Phenobarbital (rarely used)
Beta-Blockers: Propranolol
DIFFERENTIAL DIAGNOSIS OF BASAL & PARAMEDICAL PROFESSES, PULMONARY DISSEMINAT...Ankur Verma
Explore the differential diagnosis of basal and paramedical processes, pulmonary disseminations, and pulmonary infiltrates, focusing on clinical features, imaging findings, and key distinguishing factors for accurate diagnosis.
Lifestyle Medicine Overview 2025 PresentationLeslie Casey
Lifestyle medicine can address up to 80% of chronic diseases. A lifestyle medicine approach to population care has the potential to arrest the decades-long rise in the prevalence of chronic conditions and their burdensome costs. Patient and provider satisfaction often results from a lifestyle medicine approach, which strongly aligns the field with the Quintuple Aim of better health outcomes, lower cost, improved patient satisfaction, improved provider well-being, and advancement of health equity, in addition to its alignment with planetary health. Lifestyle medicine is the foundation for a redesigned, value-based and equitable healthcare delivery system, leading to whole person health.
CROUP.pdf FOR NURSING STUDENTS CREATED BY KIRAN KARETHAKIRAN KARETHA
Croup is a common childhood illness characterized by swelling
in the airway (larynx, Trachea and bronchi), leading to a
distinctive barking cough and difficulty in breathing, often with
a high-pitched, noisy sound called stridor when inhaling.
It is also known as laryngotracheobronchitis.
THE WESTLEY SCORE: classification of croup severity
SCORING SYSTEM:
A total score of < 2 indicates mild croup.
A total score of 3-5 is classifies as moderate croup.
A total score of 6-11 indicates severe croup.
A total score of >12 indicates impending respiratory failure.
The score ranges from 0-17.
MANAGEMENT:
Supportive care including intravenous fluids to maintain hydration
and oxygen inhalation to relieve hypoxia has to be given.
A single dose of dexamethasone 0.6mg/kg may decrease severity
and duration of illness.
Inhalation of epinephrine may decrease the symptoms of stridor and
respiratory distress immediately.
PREVENTION:
Many cases of croup have been prevented by immunization for
influenza and diphtheria.
Understanding the Impact of Revalidation on UK Healthcare Professionals.pdfMedical Apprisal
Revalidation UK is a vital process ensuring healthcare professionals maintain high standards, enhancing patient safety and public trust. This mandatory assessment promotes continuous professional development, requiring practitioners to demonstrate competence, adhere to ethical guidelines, and engage in reflective practice. Despite challenges like administrative burdens and balancing clinical duties, revalidation fosters lifelong learning and accountability. Employers and regulatory bodies play a key role in supporting professionals through training, mentorship, and streamlined appraisal processes. As technology advances, revalidation UK will evolve to simplify compliance and enhance accessibility. By embracing revalidation, healthcare professionals contribute to a safer, more effective healthcare system, reinforcing trust and excellence in patient care across the UK.
VENTILATORS.pptx FOR NURSING STUDENTS CREATED BY KIRAN KARETHAKIRAN KARETHA
VENTILATOR
Mechanical ventilation is a form of artificial respiration that uses a breathing machine to assist patients with breathing.
Mechanical ventilation is the use of a mechanical device to inflate and deflate the lungs.
A mechanical ventilation is a machine that generates a controlled flow of gas into a patient’s airways.
INDICATIONS
Acute lung injury
Apnea with respiratory arrest
COPD
Acute respiratory acidosis
Hypoxemia
hypercapnia
Classification of ventilators:
1. negative pressure ventilators: mechanical ventilators exert a negative pressure on the external chest. Decreasing the intrathoracic pressure during inspiration allows air to flow into the lung, filling its volume.
NEGATIVE PRESSURE VENTILATORS
1. Iron lung (drinker respirator tank)
2. body wrap and chest cuirass (tortoise shell)
POSITIVE PRESSURE VENTILATORS
1. pressure cycled ventilators
2. time cycled ventilators
3. volume cycled ventilators
4. non-invasive positive pressure ventilators
a) continuous positive airway pressure
b) bilevel positive airway pressure
AI Trends in Creative Operations 2024 by Artwork Flow.pdfmarketingartwork
Creative operations teams expect increased AI use in 2024. Currently, over half of tasks are not AI-enabled, but this is expected to decrease in the coming year. ChatGPT is the most popular AI tool currently. Business leaders are more actively exploring AI benefits than individual contributors. Most respondents do not believe AI will impact workforce size in 2024. However, some inhibitions still exist around AI accuracy and lack of understanding. Creatives primarily want to use AI to save time on mundane tasks and boost productivity.
Organizational culture includes values, norms, systems, symbols, language, assumptions, beliefs, and habits that influence employee behaviors and how people interpret those behaviors. It is important because culture can help or hinder a company's success. Some key aspects of Netflix's culture that help it achieve results include hiring smartly so every position has stars, focusing on attitude over just aptitude, and having a strict policy against peacocks, whiners, and jerks.
Classification of Selective Alpha Agonists Based on Generation
Selective alpha agonists can be classified into first-generation, second-generation, and third-generation based on their pharmacological properties, receptor specificity, and clinical applications.
1. First-Generation Selective Alpha Agonists
(Non-subtype selective, older agents, higher side effects)
These drugs act on α1 or α2 receptors but with lower specificity and more systemic side effects.
Selective α1 Agonists (Vasoconstrictors, Hypotension Treatment)
Methoxamine – Used to treat hypotension.
Phenylephrine – Used as a nasal decongestant and to increase blood pressure.
Midodrine – Used for orthostatic hypotension.
Metaraminol – Used in hypotensive states and shock.
Selective α2 Agonists (Centrally Acting, Anti-Hypertensive Drugs)
Clonidine – Used for hypertension, ADHD, and withdrawal syndromes.
Methyldopa – Used for hypertension, especially in pregnancy.
Guanfacine – Used in hypertension and ADHD.
2. Second-Generation Selective Alpha Agonists
(More receptor selectivity, improved safety profile, fewer side effects)
Selective α1 Agonists (Longer Duration, Specific Targeting)
Amidephrine – Used in hypotension.
Selective α2 Agonists (Better CNS Penetration, Neurological Uses)
Brimonidine – Used in glaucoma (reduces intraocular pressure).
Apraclonidine – Used in short-term treatment of glaucoma.
Tizanidine – Used as a muscle relaxant in spasticity.
Lofexidine – Used in opioid withdrawal treatment.
3. Third-Generation Selective Alpha Agonists
(Highly selective, fewer side effects, newer therapeutic applications)
Selective α2 Agonists (High Selectivity, Novel Applications)
Dexmedetomidine – Used as a sedative in ICU and anesthesia.
Medetomidine – Used in veterinary anesthesia.
Fadolmidine – Investigated for pain relief with fewer cardiovascular effects.
Detomidine – Used in veterinary medicine for sedation
Classification of Selective Beta Agonists Based on Generation
Selective β-adrenergic agonists can be classified into three generations based on their receptor selectivity, duration of action, and therapeutic advancements.
1. First-Generation Selective Beta Agonists
(Non-specific, Short-acting, Higher Side Effects)
Early β-agonists with partial selectivity, often affecting both β1 and β2 receptors.
Shorter duration of action, leading to frequent dosing requirements.
Key Drugs:
Isoproterenol – A non-selective β1 and β2 agonist, used for bradycardia and heart block.
Dobutamine – A selective β1 agonist, used in acute heart failure and cardiogenic shock.
Ritodrine – A selective β2 agonist, previously used for delaying preterm labor.
2. Second-Generation Selective Beta Agonists
(More Selective, Longer Duration, Improved Safety)
These drugs show improved selectivity for either β1 or β2 receptors, reducing unwanted cardiac effects.
Longer-acting compared to first-generation.
Selective β1 Agonists (Primarily Cardiac Stimulants)
Denopamine – Used in heart failure treatment.
Prenalte
Co-Chairs and Presenters, Professor Carel le Roux, MBChB, FRCP, FRCPath, PhD, and Donna H. Ryan, MD, FTOS, discuss obesity in this CME activity titled “Adopting Modern Management Strategies for Obesity: Treating the Patient, Not the Disease.” For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at https://bit.ly/40HfQWa. CME credit will be available until March 27, 2026.
echinocandins case presentation.dr ANKUSH GOYAL GMC PATIALADr Ankush goyal
Echinocandins: A Comprehensive Overview
Introduction
Echinocandins are a class of antifungal agents that have gained significant prominence in the treatment of invasive fungal infections, particularly those caused by Candida and Aspergillus species. They are considered second-line or first-line treatment options in cases of azole-resistant fungal infections. This document provides an in-depth discussion of echinocandins, including their chemical structure, mechanism of action, pharmacokinetics, spectrum of activity, clinical applications, resistance mechanisms, adverse effects, and future perspectives.
Historical Background
Echinocandins were first discovered in the late 20th century when researchers were exploring natural antifungal compounds derived from fungi and other microorganisms. The first echinocandin, pneumocandin B0, was isolated from Glarea lozoyensis. Further modifications led to the development of caspofungin, micafungin, and anidulafungin, which are the three currently approved echinocandins for clinical use.
Chemical Structure
Echinocandins are cyclic lipopeptides composed of a large cyclic hexapeptide core linked to a long-chain fatty acid side group. This unique structure is crucial for their antifungal activity and their pharmacokinetic properties. The lipid tail enhances the compound's binding affinity to fungal cells, while the cyclic peptide core is responsible for inhibiting fungal cell wall synthesis.
Mechanism of Action
Echinocandins exert their antifungal effects by selectively inhibiting the enzyme (1→3)-β-D-glucan synthase, which is essential for the synthesis of β-glucan, a major component of the fungal cell wall. The inhibition of β-glucan synthesis results in cell wall weakening, osmotic instability, and ultimately fungal cell lysis. This mechanism makes echinocandins highly selective for fungi, as mammalian cells lack β-glucan.
Pharmacokinetics
Echinocandins are administered intravenously due to their poor oral bioavailability. The pharmacokinetic properties of caspofungin, micafungin, and anidulafungin vary slightly, but they share several common features:
Distribution: Echinocandins exhibit extensive tissue penetration, particularly in the liver, spleen, lungs, and kidneys. However, their penetration into the cerebrospinal fluid (CSF) is limited, making them less effective for central nervous system fungal infections.
Metabolism: Caspofungin undergoes hepatic metabolism through hydrolysis and N-acetylation, while micafungin is metabolized by the liver via arylsulfatase and catechol-O-methyltransferase. Anidulafungin undergoes spontaneous degradation in the plasma without significant hepatic metabolism.
Elimination: The elimination of echinocandins varies; caspofungin is excreted through both hepatic and renal routes, micafungin is eliminated hepatically, and anidulafungin is primarily excreted via fecal routes due to spontaneous degradation.
Half-life: Caspofungin has a half-life of approximately 9-
The integumentary system is the largest organ system of the human body, serving as the body's first line of defense against environmental hazards. It includes the skin, hair, nails, glands, and sensory receptors. This system plays a vital role in protection, thermoregulation, sensation, excretion, and vitamin D synthesis. Understanding its structure and function is crucial for comprehending how the body interacts with its surroundings.
Structure of the Integumentary System
The integumentary system comprises two main components:
The Skin (Cutaneous Membrane)
Accessory Structures (Hair, Nails, and Glands)
The Skin
The skin, also called the cutaneous membrane, consists of three primary layers:
1. Epidermis
The epidermis is the outermost layer of the skin, composed of stratified squamous epithelium. It lacks blood vessels and is primarily made of keratinocytes, which produce the protective protein keratin. Other important cells in the epidermis include:
Melanocytes – produce melanin, which protects against UV radiation.
Langerhans cells – involved in immune response.
Merkel cells – associated with sensory neurons for touch perception.
The epidermis has five distinct layers (from deep to superficial):
Stratum basale (germinativum) – contains basal cells responsible for generating new keratinocytes.
Stratum spinosum – provides structural integrity.
Stratum granulosum – where keratinization begins.
Stratum lucidum – found only in thick skin (palms and soles).
Stratum corneum – the outermost layer made of dead keratinized cells.
2. Dermis
The dermis is the thicker, connective tissue layer beneath the epidermis. It consists of collagen and elastic fibers, providing strength and flexibility. The dermis has two layers:
Papillary Layer – composed of loose areolar connective tissue; contains dermal papillae, capillaries, and sensory receptors.
Reticular Layer – made of dense irregular connective tissue; contains sweat glands, hair follicles, and blood vessels.
3. Hypodermis (Subcutaneous Layer)
The hypodermis is a layer of adipose and connective tissue that insulates the body, stores energy, and provides cushioning. It connects the skin to underlying muscles and bones.
Functions of the Integumentary System
The skin performs several essential functions, including:
1. Protection
The skin acts as a physical barrier against microorganisms, dehydration, UV radiation, and harmful chemicals. The acid mantle (low pH) of the skin inhibits bacterial growth.
2. Thermoregulation
The skin helps maintain body temperature through:
Sweating (eccrine and apocrine glands) – evaporative cooling.
Vasodilation – blood vessels widen to release heat.
Vasoconstriction – blood vessels narrow to retain heat.
Goosebumps (arrector pili muscles) – create an insulating layer.
3. Sensation
The skin contains specialized sensory receptors:
Meissner’s corpuscles – detect light touch.
Pacinian corpuscles – sense deep pressure and vibration.
Merkel cells –
ASTHMA.pdf FOR NURSING STUDENTS CREATED BY KIRAN KARETHAKIRAN KARETHA
Asthma is defined as a chronic inflammatory disorder of the
airways (specifically bronchi and bronchioles) which
manifests itself as recurrent episodes of wheezing,
breathlessness, chest tightness and cough.
It is characterized by bronchial hyper-responsiveness and
variable airflow obstruction, that is often reversible either
spontaneously or with treatment.
ASTHMA ATTACK:
When breathe normally, muscles around the airways are relaxed,
letting air move easily and quietly. During an asthma attack, three
things can happen:
Bronchospasm: The muscles around the airways constrict (tighten).
When they tighten, it makes the airways narrow. Air cannot flow
freely through constricted airways.
Inflammation: The lining of the airways becomes swollen. Swollen
airways don’t let as much air in or out of the lungs.
Mucus production: During the attack, body creates more mucus.
This thick mucus clogs airways.
CLINICAL MANIFESTATION:
Coughing
Chest tightness
Wheezing
Shortness of breath
Chronic production of cough
Dyspnea
Cyanosis
Weight loss and anorexia
Fatigue
Anxiety
Restlessness
DIAGNOSTIC EVALUATION:
History collection
Physical examination
Chest X-ray
Spirometry
Blood test
Skin test: to identify allergic causes.
Sputum test
PFT
DIAGNOSTIC EVALUATION:
History collection
Physical examination
Chest X-ray
Spirometry
Blood test
Skin test: to identify allergic causes.
Sputum test
PFT
Shoola in Ayurveda Dr Akshay Shetty.pptxAkshay Shetty
This document deals with shoola its definition, types and difference between Parinama shoola ad Annadrava shoola with etiology,Clinical features and prognosis
Learning Objectives:
1. Explain the basis of Nernst potential and its importance in generation of resting membrane potential
2. Comprehend different mechanisms responsible for the genesis of membrane potential
3. Use the Goldman equation to explain how the relative permeability of the ions create a resting membrane potential
Psychopharmacology questions .pdf by Dr ankush goyalDr Ankush goyal
Psychopharmacology: A Comprehensive Overview
Introduction
Psychopharmacology is the scientific study of the effects of drugs on mood, perception, cognition, and behavior. It involves the interaction of drugs with the nervous system, particularly the brain, to alter mental functions and treat psychiatric disorders. Psychopharmacology integrates principles from neuroscience, pharmacology, psychiatry, and psychology to develop effective treatments for mental illnesses such as depression, schizophrenia, anxiety, and bipolar disorder.
History and Development
The field of psychopharmacology has its roots in ancient medicine, where herbal remedies were used to treat mental disorders. Modern psychopharmacology began in the 20th century with the discovery of drugs such as chlorpromazine (antipsychotic) and imipramine (antidepressant), revolutionizing psychiatric care. Over time, research has led to the development of more targeted and effective drugs with fewer side effects.
Neurotransmitter Systems and Drug Actions
Psychotropic drugs exert their effects by modulating neurotransmitter systems in the brain. The major neurotransmitters involved include:
Dopamine (DA): Associated with reward, motivation, and movement; implicated in schizophrenia and Parkinson’s disease.
Serotonin (5-HT): Regulates mood, appetite, and sleep; targeted by antidepressants.
Norepinephrine (NE): Involved in arousal and stress response; plays a role in depression and anxiety.
Gamma-Aminobutyric Acid (GABA): The primary inhibitory neurotransmitter; targeted by anxiolytics and sedatives.
Glutamate: The primary excitatory neurotransmitter; implicated in schizophrenia and cognitive function.
Acetylcholine (ACh): Important for memory and learning; affected in Alzheimer’s disease.
Classification of Psychotropic Drugs
Psychotropic drugs can be classified based on their therapeutic use:
1. Antidepressants
Used to treat depressive disorders, anxiety disorders, and other conditions.
Selective Serotonin Reuptake Inhibitors (SSRIs): Fluoxetine, Sertraline, Citalopram
Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs): Venlafaxine, Duloxetine
Tricyclic Antidepressants (TCAs): Amitriptyline, Imipramine
Monoamine Oxidase Inhibitors (MAOIs): Phenelzine, Selegiline
Atypical Antidepressants: Bupropion, Mirtazapine
2. Antipsychotics
Used to manage schizophrenia, bipolar disorder, and psychotic disorders.
Typical (First-Generation) Antipsychotics: Haloperidol, Chlorpromazine
Atypical (Second-Generation) Antipsychotics: Risperidone, Olanzapine, Clozapine
3. Mood Stabilizers
Used to treat bipolar disorder and mood dysregulation.
Lithium: Effective for bipolar disorder
Anticonvulsants: Valproate, Lamotrigine, Carbamazepine
4. Anxiolytics and Sedative-Hypnotics
Used for anxiety and sleep disorders.
Benzodiazepines: Diazepam, Lorazepam, Alprazolam
Non-Benzodiazepine Hypnotics: Zolpidem, Eszopiclone
Barbiturates: Phenobarbital (rarely used)
Beta-Blockers: Propranolol
DIFFERENTIAL DIAGNOSIS OF BASAL & PARAMEDICAL PROFESSES, PULMONARY DISSEMINAT...Ankur Verma
Explore the differential diagnosis of basal and paramedical processes, pulmonary disseminations, and pulmonary infiltrates, focusing on clinical features, imaging findings, and key distinguishing factors for accurate diagnosis.
Lifestyle Medicine Overview 2025 PresentationLeslie Casey
Lifestyle medicine can address up to 80% of chronic diseases. A lifestyle medicine approach to population care has the potential to arrest the decades-long rise in the prevalence of chronic conditions and their burdensome costs. Patient and provider satisfaction often results from a lifestyle medicine approach, which strongly aligns the field with the Quintuple Aim of better health outcomes, lower cost, improved patient satisfaction, improved provider well-being, and advancement of health equity, in addition to its alignment with planetary health. Lifestyle medicine is the foundation for a redesigned, value-based and equitable healthcare delivery system, leading to whole person health.
CROUP.pdf FOR NURSING STUDENTS CREATED BY KIRAN KARETHAKIRAN KARETHA
Croup is a common childhood illness characterized by swelling
in the airway (larynx, Trachea and bronchi), leading to a
distinctive barking cough and difficulty in breathing, often with
a high-pitched, noisy sound called stridor when inhaling.
It is also known as laryngotracheobronchitis.
THE WESTLEY SCORE: classification of croup severity
SCORING SYSTEM:
A total score of < 2 indicates mild croup.
A total score of 3-5 is classifies as moderate croup.
A total score of 6-11 indicates severe croup.
A total score of >12 indicates impending respiratory failure.
The score ranges from 0-17.
MANAGEMENT:
Supportive care including intravenous fluids to maintain hydration
and oxygen inhalation to relieve hypoxia has to be given.
A single dose of dexamethasone 0.6mg/kg may decrease severity
and duration of illness.
Inhalation of epinephrine may decrease the symptoms of stridor and
respiratory distress immediately.
PREVENTION:
Many cases of croup have been prevented by immunization for
influenza and diphtheria.
Understanding the Impact of Revalidation on UK Healthcare Professionals.pdfMedical Apprisal
Revalidation UK is a vital process ensuring healthcare professionals maintain high standards, enhancing patient safety and public trust. This mandatory assessment promotes continuous professional development, requiring practitioners to demonstrate competence, adhere to ethical guidelines, and engage in reflective practice. Despite challenges like administrative burdens and balancing clinical duties, revalidation fosters lifelong learning and accountability. Employers and regulatory bodies play a key role in supporting professionals through training, mentorship, and streamlined appraisal processes. As technology advances, revalidation UK will evolve to simplify compliance and enhance accessibility. By embracing revalidation, healthcare professionals contribute to a safer, more effective healthcare system, reinforcing trust and excellence in patient care across the UK.
VENTILATORS.pptx FOR NURSING STUDENTS CREATED BY KIRAN KARETHAKIRAN KARETHA
VENTILATOR
Mechanical ventilation is a form of artificial respiration that uses a breathing machine to assist patients with breathing.
Mechanical ventilation is the use of a mechanical device to inflate and deflate the lungs.
A mechanical ventilation is a machine that generates a controlled flow of gas into a patient’s airways.
INDICATIONS
Acute lung injury
Apnea with respiratory arrest
COPD
Acute respiratory acidosis
Hypoxemia
hypercapnia
Classification of ventilators:
1. negative pressure ventilators: mechanical ventilators exert a negative pressure on the external chest. Decreasing the intrathoracic pressure during inspiration allows air to flow into the lung, filling its volume.
NEGATIVE PRESSURE VENTILATORS
1. Iron lung (drinker respirator tank)
2. body wrap and chest cuirass (tortoise shell)
POSITIVE PRESSURE VENTILATORS
1. pressure cycled ventilators
2. time cycled ventilators
3. volume cycled ventilators
4. non-invasive positive pressure ventilators
a) continuous positive airway pressure
b) bilevel positive airway pressure
AI Trends in Creative Operations 2024 by Artwork Flow.pdfmarketingartwork
Creative operations teams expect increased AI use in 2024. Currently, over half of tasks are not AI-enabled, but this is expected to decrease in the coming year. ChatGPT is the most popular AI tool currently. Business leaders are more actively exploring AI benefits than individual contributors. Most respondents do not believe AI will impact workforce size in 2024. However, some inhibitions still exist around AI accuracy and lack of understanding. Creatives primarily want to use AI to save time on mundane tasks and boost productivity.
Organizational culture includes values, norms, systems, symbols, language, assumptions, beliefs, and habits that influence employee behaviors and how people interpret those behaviors. It is important because culture can help or hinder a company's success. Some key aspects of Netflix's culture that help it achieve results include hiring smartly so every position has stars, focusing on attitude over just aptitude, and having a strict policy against peacocks, whiners, and jerks.
PEPSICO Presentation to CAGNY Conference Feb 2024Neil Kimberley
PepsiCo provided a safe harbor statement noting that any forward-looking statements are based on currently available information and are subject to risks and uncertainties. It also provided information on non-GAAP measures and directing readers to its website for disclosure and reconciliation. The document then discussed PepsiCo's business overview, including that it is a global beverage and convenient food company with iconic brands, $91 billion in net revenue in 2023, and nearly $14 billion in core operating profit. It operates through a divisional structure with a focus on local consumers.
Content Methodology: A Best Practices Report (Webinar)contently
This document provides an overview of content methodology best practices. It defines content methodology as establishing objectives, KPIs, and a culture of continuous learning and iteration. An effective methodology focuses on connecting with audiences, creating optimal content, and optimizing processes. It also discusses why a methodology is needed due to the competitive landscape, proliferation of channels, and opportunities for improvement. Components of an effective methodology include defining objectives and KPIs, audience analysis, identifying opportunities, and evaluating resources. The document concludes with recommendations around creating a content plan, testing and optimizing content over 90 days.
How to Prepare For a Successful Job Search for 2024Albert Qian
The document provides guidance on preparing a job search for 2024. It discusses the state of the job market, focusing on growth in AI and healthcare but also continued layoffs. It recommends figuring out what you want to do by researching interests and skills, then conducting informational interviews. The job search should involve building a personal brand on LinkedIn, actively applying to jobs, tailoring resumes and interviews, maintaining job hunting as a habit, and continuing self-improvement. Once hired, the document advises setting new goals and keeping skills and networking active in case of future opportunities.
A report by thenetworkone and Kurio.
The contributing experts and agencies are (in an alphabetical order): Sylwia Rytel, Social Media Supervisor, 180heartbeats + JUNG v MATT (PL), Sharlene Jenner, Vice President - Director of Engagement Strategy, Abelson Taylor (USA), Alex Casanovas, Digital Director, Atrevia (ES), Dora Beilin, Senior Social Strategist, Barrett Hoffher (USA), Min Seo, Campaign Director, Brand New Agency (KR), Deshé M. Gully, Associate Strategist, Day One Agency (USA), Francesca Trevisan, Strategist, Different (IT), Trevor Crossman, CX and Digital Transformation Director; Olivia Hussey, Strategic Planner; Simi Srinarula, Social Media Manager, The Hallway (AUS), James Hebbert, Managing Director, Hylink (CN / UK), Mundy Álvarez, Planning Director; Pedro Rojas, Social Media Manager; Pancho González, CCO, Inbrax (CH), Oana Oprea, Head of Digital Planning, Jam Session Agency (RO), Amy Bottrill, Social Account Director, Launch (UK), Gaby Arriaga, Founder, Leonardo1452 (MX), Shantesh S Row, Creative Director, Liwa (UAE), Rajesh Mehta, Chief Strategy Officer; Dhruv Gaur, Digital Planning Lead; Leonie Mergulhao, Account Supervisor - Social Media & PR, Medulla (IN), Aurelija Plioplytė, Head of Digital & Social, Not Perfect (LI), Daiana Khaidargaliyeva, Account Manager, Osaka Labs (UK / USA), Stefanie Söhnchen, Vice President Digital, PIABO Communications (DE), Elisabeth Winiartati, Managing Consultant, Head of Global Integrated Communications; Lydia Aprina, Account Manager, Integrated Marketing and Communications; Nita Prabowo, Account Manager, Integrated Marketing and Communications; Okhi, Web Developer, PNTR Group (ID), Kei Obusan, Insights Director; Daffi Ranandi, Insights Manager, Radarr (SG), Gautam Reghunath, Co-founder & CEO, Talented (IN), Donagh Humphreys, Head of Social and Digital Innovation, THINKHOUSE (IRE), Sarah Yim, Strategy Director, Zulu Alpha Kilo (CA).
Trends In Paid Search: Navigating The Digital Landscape In 2024Search Engine Journal
The search marketing landscape is evolving rapidly with new technologies, and professionals, like you, rely on innovative paid search strategies to meet changing demands.
It’s important that you’re ready to implement new strategies in 2024.
Check this out and learn the top trends in paid search advertising that are expected to gain traction, so you can drive higher ROI more efficiently in 2024.
You’ll learn:
- The latest trends in AI and automation, and what this means for an evolving paid search ecosystem.
- New developments in privacy and data regulation.
- Emerging ad formats that are expected to make an impact next year.
Watch Sreekant Lanka from iQuanti and Irina Klein from OneMain Financial as they dive into the future of paid search and explore the trends, strategies, and technologies that will shape the search marketing landscape.
If you’re looking to assess your paid search strategy and design an industry-aligned plan for 2024, then this webinar is for you.
5 Public speaking tips from TED - Visualized summarySpeakerHub
From their humble beginnings in 1984, TED has grown into the world’s most powerful amplifier for speakers and thought-leaders to share their ideas. They have over 2,400 filmed talks (not including the 30,000+ TEDx videos) freely available online, and have hosted over 17,500 events around the world.
With over one billion views in a year, it’s no wonder that so many speakers are looking to TED for ideas on how to share their message more effectively.
The article “5 Public-Speaking Tips TED Gives Its Speakers”, by Carmine Gallo for Forbes, gives speakers five practical ways to connect with their audience, and effectively share their ideas on stage.
Whether you are gearing up to get on a TED stage yourself, or just want to master the skills that so many of their speakers possess, these tips and quotes from Chris Anderson, the TED Talks Curator, will encourage you to make the most impactful impression on your audience.
See the full article and more summaries like this on SpeakerHub here: https://speakerhub.com/blog/5-presentation-tips-ted-gives-its-speakers
See the original article on Forbes here:
http://www.forbes.com/forbes/welcome/?toURL=http://www.forbes.com/sites/carminegallo/2016/05/06/5-public-speaking-tips-ted-gives-its-speakers/&refURL=&referrer=#5c07a8221d9b
ChatGPT and the Future of Work - Clark Boyd Clark Boyd
Everyone is in agreement that ChatGPT (and other generative AI tools) will shape the future of work. Yet there is little consensus on exactly how, when, and to what extent this technology will change our world.
Businesses that extract maximum value from ChatGPT will use it as a collaborative tool for everything from brainstorming to technical maintenance.
For individuals, now is the time to pinpoint the skills the future professional will need to thrive in the AI age.
Check out this presentation to understand what ChatGPT is, how it will shape the future of work, and how you can prepare to take advantage.
The document provides career advice for getting into the tech field, including:
- Doing projects and internships in college to build a portfolio.
- Learning about different roles and technologies through industry research.
- Contributing to open source projects to build experience and network.
- Developing a personal brand through a website and social media presence.
- Networking through events, communities, and finding a mentor.
- Practicing interviews through mock interviews and whiteboarding coding questions.
Google's Just Not That Into You: Understanding Core Updates & Search IntentLily Ray
1. Core updates from Google periodically change how its algorithms assess and rank websites and pages. This can impact rankings through shifts in user intent, site quality issues being caught up to, world events influencing queries, and overhauls to search like the E-A-T framework.
2. There are many possible user intents beyond just transactional, navigational and informational. Identifying intent shifts is important during core updates. Sites may need to optimize for new intents through different content types and sections.
3. Responding effectively to core updates requires analyzing "before and after" data to understand changes, identifying new intents or page types, and ensuring content matches appropriate intents across video, images, knowledge graphs and more.
A brief introduction to DataScience with explaining of the concepts, algorithms, machine learning, supervised and unsupervised learning, clustering, statistics, data preprocessing, real-world applications etc.
It's part of a Data Science Corner Campaign where I will be discussing the fundamentals of DataScience, AIML, Statistics etc.
Time Management & Productivity - Best PracticesVit Horky
Here's my presentation on by proven best practices how to manage your work time effectively and how to improve your productivity. It includes practical tips and how to use tools such as Slack, Google Apps, Hubspot, Google Calendar, Gmail and others.
The six step guide to practical project managementMindGenius
The six step guide to practical project management
If you think managing projects is too difficult, think again.
We’ve stripped back project management processes to the
basics – to make it quicker and easier, without sacrificing
the vital ingredients for success.
“If you’re looking for some real-world guidance, then The Six Step Guide to Practical Project Management will help.”
Dr Andrew Makar, Tactical Project Management
Unlocking the Power of ChatGPT and AI in Testing - A Real-World Look, present...Applitools
During this webinar, Anand Bagmar demonstrates how AI tools such as ChatGPT can be applied to various stages of the software development life cycle (SDLC) using an eCommerce application case study. Find the on-demand recording and more info at https://applitools.info/b59
Key takeaways:
• Learn how to use ChatGPT to add AI power to your testing and test automation
• Understand the limitations of the technology and where human expertise is crucial
• Gain insight into different AI-based tools
• Adopt AI-based tools to stay relevant and optimize work for developers and testers
* ChatGPT and OpenAI belong to OpenAI, L.L.C.
The document discusses various AI tools from OpenAI like GPT-3 and DALL-E 2, as well as ChatGPT. It explores how search engines are using AI and things to consider around AI-generated content. Potential SEO uses of ChatGPT are also presented, such as generating content at scale, conducting topic research, and automating basic coding tasks. The document encourages further reading on using ChatGPT for SEO purposes.
More than Just Lines on a Map: Best Practices for U.S Bike Routes
This session highlights best practices and lessons learned for U.S. Bike Route System designation, as well as how and why these routes should be integrated into bicycle planning at the local and regional level.
Presenters:
Presenter: Kevin Luecke Toole Design Group
Co-Presenter: Virginia Sullivan Adventure Cycling Association
Asmr what is it and why did this type of video go viral on the internet
1. ASMR | What is it and why did this type of
video go viral on the internet?
After a stressful day what do you do to relax? If the answer is to leave the front of the
computer screen (or cell phone), it's time to review your concepts.
This is because the solution to problems such as stress, anxiety and even insomnia can be
exactly on the internet, more precisely on YouTube, in the acclaimed ASMR videos.
But what is ASMR? These videos are becoming increasingly popular. On YouTube, there are
already specialized channels in the production of this type of "content".
Meanwhile, on Twitch, a specific category brings together streamers doing live broadcasts of
ASMR.
ALL ASMR VIDEOS FOR YOUR REST AND RELAXATION (FREE) - https://oke.io/jU1TCN
But what is ASMR?
The acronym for Autonomous Sensory Meridian Response is nothing more than an
autonomous southern sensory response, that is, a pleasant sensation generated in the body
by an external stimulus, which in ASMR videos is usually audible or visual.
Think of sequences that can reach 60 minutes of people popping a piece of bubble wrap,
making a meal, talking softly or cutting bars of colored soap.
Currently, it is estimated that, on YouTube alone, millions of people watch ASMR productions
every day in search of relaxation, increased concentration or a better night's sleep.
ASMR and YouTube
Sometimes, staying connected on your cell phone takes our sleep away. Talking to friends
and watching news updates feels better than sleeping and makes us stay up more hours.
Difficulty turning off is a problem that has several levels and can cause insomnia.
Some people search for the solution exactly on the internet and there are YouTubers
recording videos and making use of ASMR, which promises to be the secret for those who
want to concentrate, disconnect and sleep more easily.
2. To generate more concentration, most of these productions fit only the person's face or,
sometimes, just the mouth.
These "instructors" also often make gestures towards the camera to explore the feeling of
physical and even affective contact. There are reports that, in addition to drowsiness and
concentration, these videos give a tingling sensation to those who watch.
Even without scientific evidence, Autonomous Sensory Meridian Response (ASMR) has
been making the heads of many people. Or rather, the ears.
And it has become a lucrative business for youtubers, meditation and relaxation apps.
Understand better how these sounds, almost whispered, “hypnotize” listeners (or, at least,
promise this) on our Youtube channel - ASMR SLEEP - Relaxing Music.
ALL ASMR VIDEOS FOR YOUR REST AND RELAXATION (FREE) - https://oke.io/jU1TCN
Tingling sensation
Among the ASMR effects, fans describe a tingling sensation. It was reported by 88% of
respondents to British research at Swansea University.
Camila describes this as a shiver that goes from the nape of the neck to the top of the head.
"The more you feel, it seems that it is inducing sleep, and brings a great feeling of
well-being", explains the student.
This tingling can originate in only one part of the body or vary in location. Most respondents
to the British survey reported that the tingles would originate behind the head, shoulders,
spine, arms and legs.
Benefits of ASMR
The data is part of a study by Swansea University in the UK, which questioned 475 people
who watched videos of ASMR about the benefits experienced with the practice.
● Relaxation (98%)
● Promotion of sleep (82%)
● Decreased stress (70%)
Only 5% agreed that they felt some sexual stimulation with the videos. Among those who
had chronic pain, 38% noticed improvement after joining the ASMR videos.
3. Types of ASMR content
The magic of ASMR is the trigger that will awaken the pleasurable sensations in those who
watch the videos. A Swansea University survey on the topic ranked a favorite ranking:
1. Whispers (75%)
2. Personal attention (69%)
3. Clear sounds (biting nails, scratching, etc.) (64%)
4. Slow sounds (53%)
5. Sounds repetitive (36%)
6. smile (13%)
7. airplane noise (3%)
8. vacuum cleaner noise (2%)
9. laughter (2%)
Another technique of ASMR videos is the reproduction of sounds that simulate everyday
situations that involuntarily end up having a relaxing effect on the viewer. They are called
"roleplays".
How to explain the ASMR phenomenon?
With so much demand, it is inevitable to try to understand the popularity of content as unusual
as ASMR. And perhaps the answer to what "ASMR" is lies in science.
There is still little research on the subject, but a study by the Department of Psychology at the
University of Sheffield, England, monitored the reactions of volunteers when watching
ordinary and ASMR videos.
The conclusion was that people who watched the ASMR content had their heart rates
significantly reduced and were still more relaxed and more likely to have positive thoughts.
These characteristics are similar to the sensations caused by other scientifically proven stress
reduction techniques, such as listening to music or even mindfulness, the state of mindfulness
in the present.
Although sensations such as tingling and pleasure reported by ASMR viewers are evidence
that points to the benefits reported by those who frequently watch videos, what is known in
fact is that much of this is due to the distraction factor they cause and also to the sensitivity
each one.